RAGE Expression in Human T Cells: A Link between Environmental Factors and Adaptive Immune Responses
Figure 5
Expression of RAGE on T cells from patients with T1D and T2D.
A:PBMC were isolated from patients with T1D (top two rows) and T2D (bottom row). They were stained with CD4+ or CD8+ Abs and for surface or intracellular RAGE. Two single experiments, representative of 7 are shown. B. The level of RAGE expression in unmanipulated CD4+ (solid symbols) and CD8+ (open symbols) T cells from patients with T1D, T2D, and healthy control subjects (HC) or patients with rheumatoid arthritis (RA) and Sjogren's syndrome (SS) are shown (*p<0.05, *** p<0.01). C. The relationship between hemoglobin A1c levels and the percentage of RAGE in CD4+ T cells in patients with T1 and T2D is shown (p = ns).