Salvianolic Acid B Prevents Bone Loss in Prednisone-Treated Rats through Stimulation of Osteogenesis and Bone Marrow Angiogenesis
Figure 6
Effects of different treatments on proximal tibial metaphyses (PTM) bone structure and trabecular mass.
Representative micrographs of PTM from basal (BAS), vehicle (aging) control (CON), prednisone (GC) and GC plus 80 mg Sal B/kg/d (GC+B80) treated rats. BAS: 6-month-old beginning control. CON: 9-month-old terminal vehicle control with fewer trabeculae. GC: Prednisone induced further reduction in cancellous bone mass and thinner trabeculae versus CON. GC+B80: Sal B80 treated GC rats had increased cancellous bone mass with thicker trabeculae compared to BAS and CON. (Masson-Goldner Trichrome stain: trabecular in green stain). Quantitative measurements of static parameters are shown in table 6.