Cysteamine Suppresses Invasion, Metastasis and Prolongs Survival by Inhibiting Matrix Metalloproteinases in a Mouse Model of Human Pancreatic Cancer
Figure 4
Cysteamine inhibited primary tumors and metastatic lesions in an orthotopic pancreatic cancer in vivo.
HS766T and MIA-PaCa2 cells (2×106) were implanted directly into the pancreas of 5–6 week-old female nude nu/nu mice and then peritoneal cavity and skin were closed using clips. Increasing doses of cysteamine were injected s.c. as described in materials and methods. Primary tumors and metastatic lesions of ≥ 5 mm were counted in vehicle and cysteamine treated mice. a: P<0.05, b: P<0.01 and c: P<0.05, d: P<0.001. +: moderate ascites, ++: severe ascites, –: no ascites.