Cysteamine Suppresses Invasion, Metastasis and Prolongs Survival by Inhibiting Matrix Metalloproteinases in a Mouse Model of Human Pancreatic Cancer
Figure 3
Cysteamine inhibited MMP enzyme activities in vitro.
IC50 of MMPs was determined by incubating each MMP enzyme with various concentrations of cysteamine and batimastat in a fluorimetric assay as described in materials and methods. IC50 is the concentration of inhibitor at which 50% inhibition of proteolysis occurs.