Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis
Figure 7
Theonellasterol alters the liver expression of genes involved in bile acid metabolism in BDL mice.
(A) Real-Time PCR analysis of OSTα, (B) BSEP, (C) SHP and (D) MRP4. Data are the mean ± S.E. of 4 mice per group. *P<0.05 versus sham. **P<0.05 versus BDL. #P<0.05 versus BDL plus theonellasterol.