Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis
Figure 6
BDL causes liver cell injury and theonellasterol attenuates liver necrosis.
(A and B) Liver necrosis was robustly attenuated by theonellasterol as confirmed by assessment of ALT and histopathology analysis. Data are the mean ± S.E. of 6 mice per group. *P<0.05 versus sham. **P<0.05 versus BDL. #P<0.05 versus BDL plus theonellasterol. (C) Representative liver histology from an individual mice per group. Liver sections were stained with H&E, original magnification 10×.