Amyloid Precursor Protein Is Required for Normal Function of the Rod and Cone Pathways in the Mouse Retina
Figure 5
The function of the cone pathway is altered in the APP-KO mouse.
(A) Representative waveforms of the cone ERG recorded from 3 month old WT (black) and APP-KO (grey) mice in response to the second flash of a twin flash paradigm ERG (2.1 log cd.s/m2 flash intensity). (B) The cone pathway post-photoreceptor response, the cone PII was found to be smaller in amplitude in APP-KO mice when compared with the WT response. (C) The photopic visual acuity, assessed using the optokinetic reflex to determine the spatial frequency threshold, was physiologically similar between APP-KO and WT mice with age. Results expressed as mean +/− SEM. **, p<0.01.