The Mycobacterium Tuberculosis FAS-II Dehydratases and Methyltransferases Define the Specificity of the Mycolic Acid Elongation Complexes
Figure 2
The FAS-II specialized complexes.
The FAS-II initiation complex (I-FAS-II), elongation complex 1 and 2 (E1-FAS-II and E2-FAS-II), and the termination complex (T-FAS-II) are represented as filled grey boxes. The condensing enzymes KasA, KasB and MtFabH (labeled as FabH) are in orange. The reductases InhA and MabA are respectively represented in green and yellow. The malonylCoA ACP transacylase MtFabD is represented as a red box and labeled as FabD. The interactions between KasA and KasB with either the MA-Mtf (in violet) or the condensing enzyme Pks13 (in blue) are symbolized by curved arrows. The traffic of the substrates and products of each complex is also symbolized by curved arrows and the numbers represent the sequence of the events. MA is for mycolic acids, FAS-I for fatty acid synthase of type-I and FAS-II for FAS of type-II. The product of FAS-I and substrate of FAS-II is an Acyl-CoA. The product of FAS-II is an Acyl-ACP.