Denervation Causes Fiber Atrophy and Myosin Heavy Chain Co-Expression in Senescent Skeletal Muscle
Figure 5
Fiber size in denervated versus innervated myofibers.
A: the mean fiber size of young adult (YA) myofibers where no Nav1.5 labeling was seen, versus Nav1.5 negative senescent (SEN) myofibers, Nav1.5 positive SEN ringed fibers, and Nav1.5 positive SEN cytoplasm fibers (*P<0.05 vs YA, **P<0.05 vs SEN negative, ***P<0.05 vs SEN ringed). B: the size of Nav1.5 positive fibers versus negative fibers according to the MHC labeling category in SEN muscle (*P<0.05 vs Nav1.5 negative, **P<0.05 vs ringed). C: the proportion of fibers within a given MHC labeling category that are Nav1.5 negative, Nav1.5 positive ringed, and Nav1.5 positive cytoplasm in SEN muscle (*P<0.05 vs MHC slow, **P<0.05 vs MHC slow and MHC fast).