FADS2 Function Loss at the Cancer Hotspot 11q13 Locus Diverts Lipid Signaling Precursor Synthesis to Unusual Eicosanoid Fatty Acids
Figure 2
GC results of FADS2 transfected MCF7 cells with 20∶2n−6 (8,11–20∶2) and 20∶3n−3 (8,11,14–20∶3) fatty acids.
A: FADS1-transfected cells Δ5-desaturate 20∶2n−6→5,11,14–20∶3 and 20∶3n−3→5,11,14,17–20∶4. B: FADS2 transfected cells Δ8-desaturate 20∶2n−6→20∶3n−6 and 20∶3n−3→20∶4n−3.