Positron Emission Tomography Imaging of CD105 Expression with a 64Cu-Labeled Monoclonal Antibody: NOTA Is Superior to DOTA
Figure 3
Small animal PET imaging of 4T1 tumor-bearing mice.
A. Serial coronal PET images at 4, 24, and 48 h post-injection of 64Cu-NOTA-TRC105. Tumors are indicated by arrowheads. B. Time-activity curves of tumor, liver, blood, and muscle after intravenous injection of 64Cu-NOTA-TRC105 into 4T1 tumor-bearing mice (n = 3) C. Representative PET/CT images of 64Cu-NOTA-TRC105 in 4T1 tumor-bearing mice at 48 h post-injection. D. Comparison of the 4T1 tumor uptake of 64Cu-NOTA-TRC105 and 64Cu-DOTA-TRC105. *: P<0.05.