Inhibition of hERG Potassium Channels by Celecoxib and Its Mechanism
Figure 1
(A) The hERG current in control (blue), after application of 10 µM celecoxib (green) and after wash-out (red). The currents were elicited by a 10 s pulse to −60 mV following a 10 s pre-pulse to 0 mV (HP = −80 mV). (B) Dose-response relations for the peak tail currents evoked by a pulse to −40 mV after a 2 s pre-pulse to +40 mV; here and in the following figures the dose-response relations have been fitted to the Hill equation; number of cells varied between 3 and 11.