A SILAC-Based Screen for Methyl-CpG Binding Proteins Identifies RBP-J as a DNA Methylation and Sequence-Specific Binding Protein
Figure 5
Schematic overview of RBP-J binding motifs in vitro.
RBP-J is known to bind to the RBP-J consensus motif. Binding is maintained when replacing thymine by a methyl-cytosine, whereas replacement by cytosine results in very weak binding only.