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Structural Basis of Cooperativity in Human UDP-Glucose Dehydrogenase

Figure 6

The UDP-glucose binding site.

(A, B) The active site conformations of the open and closed hexamers, respectively. (C, D) The position and hydrogen-bonding pattern of Asp280 in the open and closed hexamers, respectively. The active water molecule is shown as a black sphere. Movie S4 shows a morph between these two structures.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0025226.g006