Structural Basis of Cooperativity in Human UDP-Glucose Dehydrogenase
Figure 5
Cooperativity within the hUGDH trimeric unit.
Here, movement of the protomer A Thr131 loop into the active water-binding site is associated with an adjustment to the α6-helix, which mediates contact to the next protomer E in the trimeric unit. (A) Portions of protomers A (green), B (brown) and E (gray surface) from the open hexamer. (B) Close up of Thr131 in the active water-binding site. (C) Portions of protomers A (teal), B (orange) and E (pink surface) from the closed hexamer. (D) Close up of the active water-binding site. Movie S3 shows a morph between these two structures.