High-Throughput Screen for Identifying Small Molecules That Target Fungal Zinc Homeostasis
Figure 8
The cell model shows the four potential mechanisms of action for hit compounds to interfere with zinc homeostasis. Hit compounds can inhibit zinc uptake transporter, induce the formation of chelators or act as chelators themselves, interfere with zinc transport in or out of compartments, or modulate zinc transcription factors like Zap1.