High-Throughput Screen for Identifying Small Molecules That Target Fungal Zinc Homeostasis
Figure 1
Model of zinc-regulated gene expression.
A) Under high or normal zinc conditions Zap1 binds zinc and blocks the ZRE elements of the ZRT1 promoter and therefore inhibits GFP expression. B) Under zinc deficient conditions Zap1 releases zinc then disassociates from the ZRT1 promoter, which leads to the expression of GFP.