Newly Developed Mg2+–Selective Fluorescent Probe Enables Visualization of Mg2+ Dynamics in Mitochondria
Figure 7
Putative PD inducible substance caused Mg2+ release from mitochondria.
(A) Time-course of the change in [Mg2+]mito was measured with KMG-301 in differentiated PC12 cells. Administration of 5 mM MPP+ induced a gradual decrease of [Mg2+]mito. The error bars indicate SEM. (B) Comparison of the relative fluorescence intensities of KMG-301 10 minutes after the administration of MPP+ at the indicated concentrations. The [Mg2+]mito decreased in a dose-dependent manner. The error bars indicate SEM.