Inhibition of Lipoprotein-Associated Phospholipase A2 Ameliorates Inflammation and Decreases Atherosclerotic Plaque Formation in ApoE-Deficient Mice
Figure 5
Inhibition of lp-PLA2 attenuates inflammatory gene expression at the aortic arch and thoracic-abdominal aortas.
Lp-PLA2, MCP-1, ICAM-1, VCAM-1, TNF-α, MMP-2 and MMP-9 gene expression was determined using quantitative RT-PCR. N = 5 per group, *p<0.05, and **p<0.01 vs. vehicle.