Anti-Angiogenic and Anti-Inflammatory Properties of Kahweol, a Coffee Diterpene
Figure 8
Kahweol inhibits HUVEC MMP-2 and uPA in a dose dependent manner.
A) Gelatin zymography of MMP-2 in conditioned media of HUVEC after treatment with different kahweol concentrations. B) In situ determination of kahweol effects on HT-1080 gelatinases, as determined by gelatin zymography with the presence of kahweol in the incubation substrate buffer. C) Plasminogen zymography of HUVEC uPA after treatment with different kahweol concentrations.