Three-Dimensional Imaging of the Mouse Neurovasculature with Magnetic Resonance Microscopy
Figure 5
Multi-scale MRI of a 9L brain tumor model.
(a) In vivo T2-weighted MRI at the ‘systemic’ scale (∼150 µm); ex vivo μMRI at two ‘intermediate’ scales: (b) ∼60 µm, and (c) ∼30 µm. (d) Ultra-high resolution vascular μMRI image in which vessels have been segmented into tumor vessels (gold) and normal vessels (red). One can clearly visualize the abnormal tumor vessel architecture and changes in vessel morphology at the tumor-host tissue interface (arrows).