3′,4′-Dihydroxyflavonol Reduces Superoxide and Improves Nitric Oxide Function in Diabetic Rat Mesenteric Arteries
Figure 2
Vascular function in mesenteric arteries.
Cumulative concentration-response curves to A, ACh, B, SNP, C, ET1 and D, basal NO release in endothelium-intact mesenteric arteries. In each group of experiments (A, B), mesenteric arteries were precontracted with phenylephrine to similar level: (A) normal 59±3, normal+DiOHF 59±3, diabetic 62±2, diabeticDiOHF 60±3, (B) normal 58±2, normal+DiOHF 57±3, diabetic 61±3, diabeticDiOHF 59±4%KPSS, n = 5–12 experiments. Results are shown as mean±SEM. * p<0.05, ** p<0.01. See Table 2 or results section for pEC50 and Rmax values.