Prolonged Depression-Like Behavior Caused by Immune Challenge: Influence of Mouse Strain and Social Environment
Figure 6
Effect of LPS (0.83 mg/kg injected IP), relative to vehicle (VEH), on plasma concentrations of corticosterone as recorded 1 and 28 days after treatment under single and group housing conditions.
Trunk blood of CD1 (A) and C57BL/6 (B) mice for the corticosterone assay was taken 30 min after the FST had been started. The values are means+SEM, n = 7–8. *** P<0.01 versus vehicle-treated mice at the same time point post-treatment, + P≤0.1, +++ P<0.01 versus vehicle-treated mice tested 1 day post-treatment. In panel A it was not possible to apply a post-hoc test because two-way ANOVA failed to disclose any interaction between the factors time and treatment.