Prolonged Depression-Like Behavior Caused by Immune Challenge: Influence of Mouse Strain and Social Environment
Figure 5
Effect of LPS (0.83 mg/kg injected IP), relative to vehicle (VEH), on the behavior of C57BL/6 mice in the FST as recorded 1 and 28 days after treatment under single and group housing conditions.
The graphs show (A) the duration of immobility, (B) the duration of swimming, and (C) the duration of climbing, these parameters being expressed as a percentage of the total test duration. The values are means+SEM, n = 8. ** P<0.05, *** P<0.01 versus vehicle-treated mice at the same time point post-treatment, ++ P<0.05, +++ P<0.01 versus vehicle-treated mice tested 28 days post-treatment. In panels A (Single), B (Single) and C (Single) it was not possible to apply a post-hoc test because two-way ANOVA failed to disclose any interaction between the factors time and treatment.