The Strength and Timing of the Mitochondrial Bottleneck in Salmon Suggests a Conserved Mechanism in Vertebrates
Figure 1
Schematic illustration of two developmental genetic bottlenecks proposed to impact on mitochondrial inheritance.
A bottleneck in the female germ line has been proposed to be caused without the physical reduction of mtDNA content per cell but rather by relaxed amplification of a subset of the mtDNA population per cell (NeOog) [21]. The bottleneck during embryogenesis has been suggested to occur via random partitioning of mitochondria in the cleaving embryo resulting in a physical bottleneck at the early blastocyst stage (NeEmb) [20].