ALMS1-Deficient Fibroblasts Over-Express Extra-Cellular Matrix Components, Display Cell Cycle Delay and Are Resistant to Apoptosis
Figure 2
Distribution of differentially expressed genes in ALMS fibroblasts.
Fibroblast transcriptional profiles were analyzed by whole genome expression experiments using RNA isolated from healthy controls and ALMS fibroblasts. (a) Pie chart shows the percentage of differentially expressed genes (n = 560) in ALMS fibroblasts clustered in main categories: cell cycle (n = 90), ECM components/fibrosis regulation (n = 37), cellular adhesion/motility (n = 24) and apoptosis (n = 18). (b) Bar chart displays the distribution of up- (black) and down- (grey) regulated genes for each identified group with the number of corresponding genes. A detailed description of the whole genome expression analysis is given in Table S2.