Adverse Events Post Smallpox-Vaccination: Insights from Tail Scarification Infection in Mice with Vaccinia virus
Figure 3
Clinical signs and lesion kinetic in T and B-cell deficient mice.
Rag1−/− animals (n = 6) were infected with 107 p.f.u. of VACV-WR by tail scarification. (A) Clinical signs of disseminated disease in Rag1−/−. Starting on the second week post-infection, Rag1−/− mice had signs of generalized disease, such as ruffled fur, arched back and disseminated lesions, primarily at the face, forepaw and tail. The animal shown is representative of the group. (B) Rag1−/− presented a delayed lesion healing compared to WT mice. Note the ulcerative, purulent nature of the lesion in Rag1−/− compared to the scab formed in C57BL/6 animals. Photos are representative of the groups indicated. Black bar represents 1 cm.