Adverse Events Post Smallpox-Vaccination: Insights from Tail Scarification Infection in Mice with Vaccinia virus
Figure 2
T and B-cell deficient mice had severe disease upon tail scarification infection with VACV-WR.
Rag1−/− animals (n = 6) were infected with 107 p.f.u. of VACV-WR by tail scarification. (A) Weight curve of infected or mock-infected Rag1−/− mice (**p<0.01, unpaired t test). (B) Animals were followed during 60 days post-infection (p.i.) to compute mean survival (**p<0.01, log-rank test). (C) WT and Rag1−/− animals were euthanized at the times indicated and the tail, spleen and ovaries were removed and titrated in BSC-40 cells. Bars represent the mean and standard error (SEM). The results are representative of three experiments.