Modification of Collagen by 3-Deoxyglucosone Alters Wound Healing through Differential Regulation of p38 MAP Kinase
Figure 7
Diagram of p38 MAPK regulation of wound healing on native collagen and 3DG-collagen.
Under normal wound healing phosphorylation of p38 MAPK activates AKT and ERK1/2 to promote migration, proliferation, and collagen production. During diabetic wound healing, 3DG-collagen negatively impacts the dermal fibroblast by phosphorylating p38 MAPK to downregulate the expression of ERK1/2 and AKT and promote reduced cell proliferation and migration.