Inhibition of Anaplastic Lymphoma Kinase (ALK) Activity Provides a Therapeutic Approach for CLTC-ALK-Positive Human Diffuse Large B Cell Lymphomas
Figure 5
Effect of the ALK inhibitor TAE-684 on the growth of LM1 and Karpas422 xenografts.
A: Tumor growth plot in LM1 xenografted mice treated with vehicle (blue circles) or TAE-684 at 10 mg/kg/day 5 days per week for 2 weeks (red circles). The mice were followed without treatment until the tumors reached 1500 mm3 when the mice were killed (beginning of week 5). The treated mice were followed without further treatment for a total of 16 weeks when they were also killed. The treated mice had no macro or microscopic evidence of tumor relapse. The Y-axis indicates tumor volume (in mm3) and X-axis days of treatment. B: The same experiment as in panel A but using Karpas422 mice. In this case all the mice were killed when the tumors reached 1500 mm3 (at the end of week 5). C: Adjusted body weight at week 5 in the Karpas422 and LM1 mice for the control and TAE-684-treated animals. The error bars represent the SEM.