Integrated Analysis of Gene Expression, CpG Island Methylation, and Gene Copy Number in Breast Cancer Cells by Deep Sequencing
Figure 4
There is an inverse correlation between methylation status of promoter-proximal CpG islands and mRNA abundance.
Panel A: A scatter plot and trend line between fold change of gene expression and mean difference of methylation between ER+ and ER− cell lines. The Pearson correlation coefficient R is −0.75 [95%CI: −0.81, −0.68] with p-value<2.2e-16. Panel B: The distance from the start of each of the CpG islands that exhibited inverse correlation with mRNA abundance, illustrated in Figure A, to the start of the corresponding gene plotted against log2 gene expression fold change between ER+ and ER− cell lines. Panel C: A histogram representing the distribution of differentially methylated CpG islands in 149 differentially expressed genes.