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Phosphorylation-Dependent 14-3-3 Binding to LRRK2 Is Impaired by Common Mutations of Familial Parkinson's Disease

Figure 4

S935A mutation does not affect LRRK2 dimerization.

(A, B) FLAG-LRRK2 WT or S935A mutant construct was co-transfected with HA-LRRK2 constructs. The Co-IP assay was performed using either anti-HA (A) or anti-FLAG (B) antibody, followed by Western blot analysis using the indicated antibodies.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0017153.g004