A Broadly Flavivirus Cross-Neutralizing Monoclonal Antibody that Recognizes a Novel Epitope within the Fusion Loop of E Protein
Figure 5
Protection of 2A10G6 against DENV 1-4 in suckling mice.
2A10G6 at 100, 20, or 4 µg/ml was incubated with 104 PFU/ml of DENV 1–4 and inoculated into brains of suckling mice. Mortality was the outcome measured. Viruses with PBS were included as a negative control. The number of animals for each antibody dose ranged from 9 to 12. Kaplan–Meier survival curves were analyzed by the log-rank test and compared to curves of the PBS controls. Significant differences are indicated by asterisks (*** p<0.001, ** p<0.01 and * p<0.05). A, B, C, and D represent DENV1, DENV2, DENV3, and DENV4 infection, respectively.