Serum Lipidomics Meets Cardiac Magnetic Resonance Imaging: Profiling of Subjects at Risk of Dilated Cardiomyopathy
Figure 2
Logistic regression model using only one lipid variable, TG(49∶3), moderately discriminates subjects at risk of DCM from the controls.
The model was trained using samples from Lamin+ study (LMNA mutation carriers and their controls) and applied to samples from Lamin− (DCM patients without LMNA mutation and their controls). (A) Parameter estimates, their standard errors and the z- and p-values of the estimates of the logistic regression model. Negative parameter estimate indicates that the risk of DCM increases with lowering concentrations of TG(49∶3). (B) Model performance and (C) and ROC curves in Lamin+ and Lamin− studies. Lower levels of TG(49∶3) do not depend on the lamin mutation (panel D) but are DCM specific (panel E).