Characterization of a Novel Interaction between Bcl-2 Members Diva and Harakiri
Figure 7
3D model of the Diva/Harakiri heterodimer compared to other prosurvival/BH3_peptide complexes.
(A,B,C) Surface and ribbon representation of the Diva/Hrk_ΔTM heterodimer (A), Mcl-1/Bid_BH3 (pdb ID 2KBW) (B) and Bcl-XL/Bad_BH3 (pdb ID 2BZW) (C) complexes. The interacting surface in Diva and the other prosurvival proteins is colored in orange. The BH3-only protein fragments are shown as green ribbons and the N-termini are indicated. Residues Arg 22, Ala 54 and Ala 59 in Hrk_ΔTM are indicated to show that the N and C-terminal regions of the cytosolic domain of Harakiri are outside the critical binding region. The orientation of the three complexes is equivalent. Fig. 7 was created with MOLMOL [42].