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Motor Network Degeneration in Amyotrophic Lateral Sclerosis: A Structural and Functional Connectivity Study

Figure 5

Selection of corticospinal tract (CST) and corpus callosum (CC) fibers.

First, all fibres were tracked. Secondly, the left precentral gyrus was selected as region of interest (ROI 1) and the fibres touching this ROI were selected. Thirdly, the brainstem was selected as second ROI (ROI 2a). The left CST was defined by all fibres touching both ROI 1 and ROI 2a. Finally, a third ROI (ROI 2b) was defined as the right precentral gyrus. The CC was defined by all fibres touching both ROI 1 and ROI 2b. The tracts of the right CST were defined in a similar manner. ROI = region of interest. PCG = precentral gyrus. CST = corticospinal tract. CC = corpus callosum.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0013664.g005