Antibody Targeting of Cathepsin S Inhibits Angiogenesis and Synergistically Enhances Anti-VEGF
Figure 3
Fsn0503 inhibits angiogenesis in vivo; CD34 Immunohistochemical analysis of Fsn0503 treated tumors.
(A) Pattern of small vessel (white arrows) and large vessel (black arrows) distribution in isotype control and Fsn0503 treated tumors (10 mg/kg 5 times a week for 4 weeks) (20×). (B) Analysis of total vessel number as characterized by CD34 staining shows that Fsn0503 caused an increase in small vessel number and a significant decrease in the number of large vessels (p<0.001). (C) A significant reduction is observed in the mean vessel area of tumours treated with Fsn0503 (p<0.001).