Epstein-Barr Virus Interferes with the Amplification of IFNα Secretion by Activating Suppressor of Cytokine Signaling 3 in Primary Human Monocytes
Figure 7
Proposed mechanism for EBV-mediated interference with type I IFN secretion by human monocytes.
Following entry into the cell, EBV induces IRF3/7 activation leading to the initial production of IFNα/β. EBV infection also induces the synthesis of SOCS3 protein which results in inhibition of IFN receptor (IFNR) signaling and also in inhibition of the amplification of IFNα/β production. ISGs: interferon-stimulated genes. Black lines indicate “activation” and red lines indicate “suppression”. Red dotted lines represent suppressive effects of SOCS protein activation on JAK/STAT signaling events.