DCB-3503, a Tylophorine Analog, Inhibits Protein Synthesis through a Novel Mechanism
Figure 1
DCB-3503 down regulated expression of cyclin D1, survivin, β-catenin, p53, and p21.
(A) Structure of DCB-3503. (B) and (C) HepG2 cells and HeLa cells were treated with DCB-3503 for the indicated time and dose. Whole cell lysates were probed with antibodies as indicated. β-Actin blot was used as internal loading control. D. Down-regulation of cyclin D1 by DCB-3503 in Huh7 and MCF-7 cells. B, C, and D are representatives from at least three separate experiments. (* Indicating non-specific band).