Inhibition of StearoylCoA Desaturase Activity Blocks Cell Cycle Progression and Induces Programmed Cell Death in Lung Cancer Cells
Figure 5
Effect of exogenous fatty acids on the levels of lipids in SCD1-deficient cells.
H460 lung cancer cells were treated with 1 µM CVT-11127 (CVT) for 48 h in presence or absence of 100 µM oleic acid (Ole). Total cell lipids were extracted, separated by TLC and stained with iodine vapors (A). Relative levels of, triacylglycerols (B), cholesterolesters (C), and phospholipids (D), were determined by densitometric scanning. *, p<0.05 or less, vs DMSO; **, p<0.05 or less vs CVT-treated control, by Student's t test.