Conformational Determinants of Phosphotyrosine Peptides Complexed with the Src SH2 Domain
Figure 8
Hydrogen bonds formed by Asn(pY+2) in pYVNV and pYENI complexed with SH2 domains.
(A) pYVNV complexed with the ThrEF1Trp mutant of Src SH2; (B) pYVNV complexed with wt Src SH2 (representative of the major cluster); (C) pYENI complexed with wt Src SH2 (representative of the major cluster). The phosphopeptide backbone is represented as a cartoon.