Conformational Determinants of Phosphotyrosine Peptides Complexed with the Src SH2 Domain
Figure 5
Conformational trends of the pYEEX series of peptides complexed with the Src SH2 domain.
(A) Cartoons of representative structures of the “extended” conformation cluster of the pYEEX series superimposed on the structure of pYEEI complexed with the Src SH2 domain; (B) Representative structures of the “helical” conformation cluster of pYEEX series, superimposed on an ideal helix. The reference conformations for extended and helical clusters are in magenta, pYEEI, red, pYEEL, yellow, pYEEV, green, pYEEA blue, pYEEG, light blue.