α-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population
Figure 6
Insulin-mediatedglucose disposal rates and representative metabolite levels in insulin resistant and dysglycemic subjects.
A. Box plots of insulin-mediated glucose disposal rates (MFFM, µmol·min−1·kgFFM−1); derived from the clamp in normoglycemic (NGT) and dysglycemic (IGT, FPG) subjects. B. – F. Box plots of concentrations (µg/ml) of representative metabolites that change significantly with insulin resistance and/or dysglycemia as measured by isotopic dilution assays in subjects with normal glucose tolerance that are insulin sensitive (NGT-IS) or insulin resistant (NGT-IS) and in dysglycemic subjects with impaired glucose tolerance (IGT) or impaired fasting plasma glucose levels (IFG). B. α-HB, C. linoleoyl-GPC, D. decanoyl-carnitine, E. glycine, F. palmitate.