Cannabinoid-Mediated Inhibition of Recurrent Excitatory Circuitry in the Dentate Gyrus in a Mouse Model of Temporal Lobe Epilepsy
Figure 8
Western blot detection of cannabinoid type 1 receptor (CB1R) expression.
A. Diagram of dentate gyrus illustrating the area that was micro-dissected (box) for analysis. B. Western blot showing CB1R expression in pilocarpine-treated mice that survived SE and developed TLE compared to untreated mice. Actin was used as the loading control, which did not change significantly. C. Graph showing cumulative (60%) increase in CB1R expression in mice with TLE versus controls (n = 6; p<0.05). * indicates significance. IML, inner molecular layer; GCL, granule cell layer; PML, polymorphic layer.