Cannabinoid-Mediated Inhibition of Recurrent Excitatory Circuitry in the Dentate Gyrus in a Mouse Model of Temporal Lobe Epilepsy
Figure 6
Anandamide attenuated secondary population activity that followed antidromic stimulation of granule cell axons.
A. Trace showing granule cell response to mossy fiber stimulation in a mouse with TLE. B. Antidromically-evoked secondary afterdischarges were reduced in the presence of 1 µM AEA. C. The effect of AEA was reversible after 30 min wash to control ACSF. Recordings were made in the absence of Mg2+ and the presence of 30 µM bicuculline; stimulus intensity 0.1 mA.