A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo
Figure 9
Weekly repeated dosing at 5 mg/kg of the LNA ASO led to a stable reduction of PCSK9 mRNA (A), unchanged levels of LDLR mRNA (B) and 2–3 fold up-regulation of LDLR protein levels (C) (white bars: Saline, black bars: LNA ASO) (Mean and SD, n = 4–5).