Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin
Figure 2
IDE inhibition by a focused library of retro-inverso peptide hydroxamates containing modifications at the P1' position.
A, Structure of compound library. Note that compounds were generated in the retro-inverso configuration (see Fig. S2). B, Relative Ki values of inhibitors containing different R groups (see A).