MAPk Activation Modulates Permeability of Isolated Rat Alveolar Epithelial Cell Monolayers Following Cyclic Stretch
Figure 5
JNK inhibition prevents loss of occludin.
Occludin concentration in cell monolayers significantly drops following 60 minutes of stretch (0.25 Hz, 37% ΔSA) compared to unstretched monolayers (*, p<0.05). Treatment with the JNK inhibitor SP600125 blocked occludin decreases following 60 minutes of stretch, however ERK inhibition with U0126 did not. (N≥3, μ ± SE).