Endocannabinoids Differentially Modulate Synaptic Plasticity in Rat Hippocampal CA1 Pyramidal Neurons
Figure 5
Depolarization-induced suppression of excitation (DSE) is present at the SC, but not at the PP.
A1. Representative traces of EPSCs recorded before and after a somatic depolarizing step from −70 to 0 mV for a 10 sec duration at the PP and SC of a rat pyramidal neuron. A2. Time courses of DSE at the PP and SC. B1. Representative traces of EPSCs recorded before and after a dendritic (200 µm from the soma) depolarizing step from −70 to 0 mV for a 10 sec duration at the SC of pyramidal neurons in the absence and presence of RIM (2 µM). B2. Time courses of DSE induced by dendritic depolarization at the SC. C1. Representative traces of EPSCs recorded before and after a dendritic (280 µm from the soma) depolarizing step from −70 to 0 mV for a 10 sec duration at the PP of a pyramidal neuron. B2. Time courses of DSE induced by dendritic depolarization at the PP. Scale bars: 200 pA/50 msec.