Permanent Occlusion of Feeding Arteries and Draining Veins in Solid Mouse Tumors by Vascular Targeted Photodynamic Therapy (VTP) with Tookad
Figure 5
Tookad-VTP induced increase in arterial blood flow rate and volume.
Arterial blood flow rates and volumes were monitored in the tumor FA during VTP. Baseline (100%) was defined by the average of LC recordings (gray background). Data analyzed at a 2 sec time resolution is presented as the mean ± SEM (n = 5). A prompt, but transient ≤60% increase in arterial blood flow velocity, followed by an up to 70% elevation in FA blood volume was observed upon initiation of VTP. Approximately twenty seconds later, a gradual decline in the arterial blood volume and flow rate was observed to the point of complete vascular collapse, whereby stasis was observed at tVTP≅60 seconds.